Five guys are gathered in a room praying and worshipping God, and the Holy Spirit speaks to them, saying he wants them to send Saul and Barnabas out on a new mission. We’re not told it was an audible voice or an impression on their souls, but the Holy Spirit spoke. There are times when you will be praying and waiting on God, when a new and unexpected word will come in such a way that you have no choice but to obey. When you obey and run into problems along the way, you will face the temptation to question whether or not you made the right decision. But in these moments of doubt, you can fall back on the Words of God and rely on him as your source of strength; and you can press on knowing it was God who directed you. Keep on praying and fasting and listening for continued guidance from the Lord.
Now in the church at Antioch there were prophets and teachers: Barnabas,Simeon called Niger, Lucius of Cyrene, Manaen (who had been brought up with Herod the tetrarch) and Saul. While they were worshiping the Lord and fasting, the Holy Spirit said, “Set apart for me Barnabas and Saul for the work to which I have called them.” So after they had fasted and prayed, they placed their hands on them and sent them off.